August 10, 2026 12:56 pm EDT

The Inbetweeners star James Buckley has revealed he has been diagnosed with a genetic disease. 

The actor, 38, said he underwent a health check after his wife Clair was taken to hospital in an ambulance suffering from severe dehydration. 

James then asked doctors for further tests after a blood test he had done previously highlighted concern. 

In this week’s episode of The Buckleys podcast, James revealed he is at risk of cardiovascular incident due to having high Lipoprotein(a), a genetically inherited type of blood cholesterol, and has had to give up drinking and cut down on takeaways. 

It promotes faster plaque buildup in arteries, increases inflammation and increases the risk of blood clotting. 

It affects roughly one in five people worldwide, typically presenting no physical symptoms until a cardiovascular event occurs. 

The Inbetweeners star James Buckley has revealed he has been diagnosed with a genetic disease

 James revealed he is at risk of cardiovascular incident due to having high Lipoprotein(a), and has given up drinking and cut down on takeaways

He explained: ‘I’ve also had health problems as well. It’s something to do with my Lipoprotein(a), something to do with that.

‘There’s nothing you can do about it, by the way. And the doctor’s just been like, “you need to change”.’ 

James has given up drinking for the time being and overhauled his diet. 

He went on: ‘I’m at a high risk now for a cardiovascular incident. My heart, my arteries. I’m not a religious man, but sometimes I feel like there is a God that sort of goes “that’ll teach you”. 

‘I feel like I’ve been on this podcast slagging people off that don’t drink. Yeah, we have boring stuff. And now I’ve been told to try not [laughter] in rein it in [sic].

‘But I’m going to have a beer soon.’

James added he is also worried because it’s genetic that their two sons may have inherited it. 

The actor, 38, said he underwent a health check after his wife Clair was taken to hospital in an ambulance suffering from severe dehydration

WHAT IS HIGH CHOLESTEROL?

Cholesterol is a fatty substance that is vital for the normal functioning of the body.

But too much can cause it to build up in the arteries, restricting blood flow to the heart, brain and rest of the body.

This raises the risk of angina, heart attacks, stroke and blood clots. 

Cholesterol is made in the liver and is carried in the blood by proteins.

The first – high-density lipoprotein (HDL) – carries cholesterol from cells to the liver where it is broken down or passed as waste. This is ‘good cholesterol’.

‘Bad cholesterol’ – low-density lipoprotein (LDL) – carries cholesterol to cells, with excessive amounts then building in the artery walls.

High cholesterol can be genetic but it is also linked to a diet rich in saturated fat, as well as smoking, diabetes, high blood pressure and a family history of stroke or heart disease. 

Blood cholesterol is measured in units called millimoles per litre of blood, often shortened to mmol/L.

A healthy adult’s overall level should be 5mmol/L or less, while their LDL level should be no more than 3mmol/L. An ideal level of HDL is above 1mmol/L.

Cholesterol can be lowered by eating a healthy, low-fat diet; not smoking; and exercising regularly.

If these do not help, cholesterol-lowering medication like statins may be prescribed.

Source: NHS  

It comes after reports a new Inbetweeners movie is on the horizon – with all four core members of the cast set to return.

The show became an instant classic when it aired for three seasons between 2008 and 2010, with two film spinoffs made as well.

While there have been whispers in the past about a reboot, The Sun has now claimed that the four main actors, namely Simon Bird, Joe Thomas, James Buckley and Blake Harrison, have all signed on the dotted line to star in a third movie for Netflix.

However, the newspaper also said that streaming bosses aren’t satisfied with just the main men returning – they also want to see Emily Atack, 36, reprise her role as Charlotte ‘Big Jugs’ Hinchcliffe.

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