Jared Leto lost a major role in political thriller “Assassination” amid sexual misconduct allegations, multiple sources close to production exclusively told Page Six. Sources allege the “Dallas Buyers Club” star was in advanced talks to join “Rain Man” director Barry Levinson’s “Assassination” in 2025 before production ultimately passed on casting the actor amid mounting sexual misconduct allegations. Leto was reportedly “extremely interested” in joining the film and had been in ongoing conversations with Levinson about the role — with one source describing the casting as “seeming like a done deal.” But behind the scenes, production…